Gored 80mg Tablet

Uses of Gored 80

• Type II Diabetes Mellitus

How does Gored 80mg Tablet work?

Gored 80mg Tablet effectively controls blood sugar levels by promoting increased insulin secretion from the pancreas to digest circulating sugars (glucose) in the blood. It also enhances the body's sensitivity to insulin, helping utilize circulating blood glucose and leading to a decrease in blood glucose levels.

Side Effects of Gored 80

• Dizziness
• Nausea or vomiting
• Weakness
• Sweating
• Changes in vision
• Decreased heartbeat
• Stomach pain
• Constipation
• Skin rash
• Elevated liver enzymes
• Hypoglycemia (low blood sugar levels)

Quick Suggestions:

• Take Gored 80mg Tablet shortly before or with the first main meal of the day (usually breakfast) and avoid skipping meals.
• Be cautious while driving or operating machinery until you know how Gliclazide affects you.
• It may cause low blood sugar (hypoglycemia) when used with other antidiabetic medicines, alcohol, or if you delay or miss a meal.
• Carry sugary food or fruit juice in case of hypoglycemic symptoms. Your doctor may monitor your liver function regularly.
• Fill half your plate with starchy veggies, a quarter with proteins, and a quarter with whole grains.
• Eat at regular intervals and monitor blood sugar levels regularly. Gradually lose weight to achieve a healthy BMI. Reduce saturated fat intake and manage stress.
• Keep blood pressure normal (120/80mmHg) to reduce the risk of cardiovascular diseases in diabetes patients.
• Follow your doctor's directions and inform them of any other medicines or supplements you are taking.
• Be aware of early symptoms of high/low blood sugar levels.

Indication of Gored 80mg Tablet

Gored 80mg Tablet is an anti-diabetic medicine for type 2 Diabetes mellitus. It controls blood sugar levels and prevents complications like blindness, kidney damage, stroke, and heart attack. It stimulates insulin production, reducing excess blood sugar.

Pharmacology

Gliclazide works by stimulating insulin secretion from pancreatic beta-cells, which helps in reducing blood sugar levels. It also decreases insulin uptake and glucose output by the liver, leading to better control of blood glucose. Additionally, it increases insulin sensitivity at peripheral target sites, making the body more responsive to insulin.

Furthermore, Gliclazide has beneficial effects on micro thrombosis by partially inhibiting platelet aggregation and adhesion. It also helps in restoring fibrinolysis by increasing tissue plasminogen activator (t-PA) activity, which aids in breaking down blood clots.

Overall, Gliclazide plays a crucial role in managing diabetes by regulating insulin levels and promoting better glucose utilization in the body, thus preventing complications associated with high blood sugar levels.

Dosage & Administration of Gored 80mg Tablet

The adult dose of Gored 80mg Tablet for type 2 diabetes mellitus is as follows:

• Regular-release tablets: Initially, 40-80 mg daily, gradually increased up to 320 mg daily if necessary. Doses greater than 160 mg daily are given in 2 divided doses.
• Modified-release tablets: Initially, 30 mg once daily, with the possibility of increasing in increments of 30 mg up to a maximum of 120 mg daily. The interval between dose increments should be at least 1 month. For non-respondent patients, the dose may be increased after 2 weeks.

It is important to take Gored 80mg Tablet before meals or as advised by your physician. Swallow the medicine with a glass of water, and do not crush or chew the medicine.

Your doctor will determine the correct dose and duration of therapy based on your age, body weight, and the severity of your condition. It is essential to continue taking Gored 80mg Tablet for the duration recommended by your doctor to achieve better control over blood sugar levels.

Interaction

Gliclazide can interact with various other medicines, and it is important to be cautious while using it in combination with the following:

• Medicines used to treat high blood sugar: Avoid combining Gliclazide with other oral antidiabetics, GLP-1 receptor agonists, or insulin, as it may lead to excessively low blood sugar levels (hypoglycemia).
• Antibacterial drugs: Gliclazide may interact with sulfonamides and clarithromycin, affecting its efficacy or causing adverse effects.
• Medications for high blood pressure or heart failure: Captopril and enalapril, used to treat these conditions, may interact with Gliclazide, leading to blood pressure fluctuations.
• Medicines for fungal infections: Miconazole and fluconazole may interact with Gliclazide, affecting its metabolism or leading to unwanted effects.
• Drugs for indigestion and ulcers: H2 receptor antagonists like ranitidine can interact with Gliclazide, influencing its absorption and action.
• Medicines for depression: Monoamine oxidase inhibitors like selegiline and phenelzine may interact with Gliclazide, leading to unwanted effects.
• Painkillers and anti-inflammatory medications: Ibuprofen and phenylbutazone can interact with Gliclazide and affect blood sugar levels.
• Blood thinner/anticoagulant medication: Warfarin's effects may be altered when used along with Gliclazide, increasing the risk of bleeding.
• Medicines containing alcohol: Combining Gliclazide with alcoholic beverages may increase the risk of hypoglycemia (low blood sugar).

It is essential to avoid Gliclazide in patients with severe liver or kidney problems, severe thyroid or adrenal gland problems, or those who have experienced a diabetic coma, as it may worsen their condition. Always consult your doctor before taking Gliclazide and inform them about all the medications and medical conditions you have to prevent any potential interactions or complications.

Contraindications

If you have any of the following conditions or situations, you should not take (Gliclazide):

1. Allergic to gliclazide or any of the other ingredients in the tablet.
2. Diagnosed with type 1 diabetes.
3. Experiencing kidney or liver problems.
4. Presence of ketones and sugar in the urine.
5. Undergoing diabetic pre-coma or coma.
6. Diabetic patients undergoing surgery, experiencing severe trauma or having infections.
7. Suffering from a hereditary disease called porphyria.
8. Taking a medicine called miconazole to treat fungal infection.
9. Currently breastfeeding.

In these cases, it is essential to inform your doctor about your medical history and conditions so that they can prescribe the most suitable alternative treatment for your diabetes.

Pregnancy & Lactation

Pregnant women should avoid using gliclazide. It should not be used by a woman who is breastfeeding.

Precautions & Warnings

Gored 80mg Tablet should not be used in patients with type 1 diabetes or diabetic ketoacidosis, as it is not effective in these conditions. Additionally, it should not be taken by individuals who are allergic to Gliclazide or any of its ingredients, have severe liver or kidney problems, have severe thyroid or adrenal gland problems, or have a history of diabetic coma.

Patients taking Gliclazide should be aware of the rare but serious condition called lactic acidosis, where too much lactic acid builds up in the blood. Proper liver and kidney function are necessary to eliminate excess lactic acid from the blood. Therefore, it is essential to consult a doctor and take Gliclazide only under medical supervision.

Gliclazide is most effective when combined with healthy lifestyle changes, such as weight loss, regular exercise, and a healthy diet, to achieve better control over blood sugar levels in patients with type 2 diabetes mellitus.

Storage Conditions

Store Gored 80mg Tablet below 25°C at a dry place, protected from light. Keep it away from children and pets.